Journal Articles

Kasserra, C.E., Harris, P., Stenton, G.R., Abraham, W., Langlands, J.M. (2004) IPL576,092, a novel anti-inflammatory compound, inhibits leukocyte infiltration and changes in lung function in response to allergen challenge. Pulm. Pharmacol. Ther. 17, 309-318

Juniper, E.F, Langlands, J.M, Juniper, B.A . (2008) Patients may respond differently to paper and electronic versions of the same questionnaires. Eur. Resp. J. 103, 932-934 DOI: 10.1016/j.rmed.2008.10.019

Guo, C., Yang, Q., Li, J., Wu, S., Deng, M, Du., X., Sai, K., Jiang, X., Chen, Z., Zhang, J., Lin, F., Wang, J., Ju, X., Mou, Y., Bacha, J., Steino, A., Kanekal, S., Kwan, C., Johnson, G., Schwartz, R., Langlands, J., Brown., D., Chen, Z-P. (2019) Phase 2 clinical trial of VAL-083 as first-line treatment in newly-diagnosed O-6-methylguanine-DNA methyltransferase-unmethylated glioblastoma multiforme: halfway report. Glioma 2 (4), 167-173 DOI: 10.4103/glioma.glioma_25_19

Ramos L, Truong S, Zhai B, Joshi J, Ghaidi F, Lizardo MM, Shyp T, Kung SHY, Rezakhanlou AM, Oo HZ, Adomat H, Le Bihan S, Collins C, Bacha J, Brown D, Langlands J, Shen W, Lallous N, Sorensen PH, Daugaard M. (2023). A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma. Clin Cancer Res, 29(17), 3541-3553. Doi:10.1158/1078-0432.Ccr-22-3897

Guo C, Yang Q, Deng M, Qiu X, Wu S, Du X, Sai K, Dai Z, Chen Z, Zhang J, Lin F, Ke C, Xi S, Hu W, Zhou Z, Li J, Cao X, Liao Y, Lv Y, Brown D, Langlands, J, Johnson G, Bacha J, Kwan C, Kanekal S, Schwartz R, Chen Z. VAL-083 is effective in patients with newly-diagnosed MGMT-unmethylated glioblastoma: report of phase II study. Discov Oncol. 2025 Dec 12. doi: 10.1007/s12672-025-04235-y. Epub ahead of print. PMID: 41385182.

Selected Conference Presentations

Langlands, J.M., Rodger, I.W., and Watson, J. (1987) Effect of methacholine and leukotriene D4 on cyclic AMP-dependent protein kinase activity in airway smooth muscle. Br. J. Pharmacol. 92, 633P

Langlands, J.M., Rodger, I.W. (1988) Effects of histamine on cyclic AMP-dependent protein kinase activity, cyclic GMP and inositol trisphosphate in airway smooth muscle. Br. J. Pharmacol. 95, 510P

Langlands, J.M., Diamond, J., Rodger, I.W., (1989) Modification of methacholine- and histamine-induced stimulation of IP3 in airway smooth muscle. Br. J. Pharmacol. 97, 445P

Langlands, J.M., Diamond, J. (1991) The effect of methacholine on protein kinase C in bovine tracheal smooth muscle. FASEB. J. 6, A1633

Bramley, A.M., Langlands, J.M., Pendleton, N., Burgoyne, D.L., Anderson, R.J., Salari, H. (1995) Oral IZP-94005 administration inhibits ovalbumin-induced responses in sensitized guinea-pigs. Am. J. Resp. Crit. Care Med. 151, A383

Langlands, J., Abraham, W., Harris, P., Kasserra, C. Marked reductions in both early and late phase responses to allergen challenge in animal models of asthma with IPL576,092. Abstract 326, 57th Annual Meeting of the American Academy of Allergy, Asthma and Immunology, New Orleans, March 16-21, 2001

Langlands, J, LaForce C. The effect of IPL512,602 in patients with mild-moderate persistent asthma (NEAT Study). (2006) Proceedings of the American Thoracic Society Vol 3 Abstracts Issue, A80

Chen, Z.-p., Guo, C.-C., Qun-ying, Y., Li, J.-W., Wu, S.-x., Bacha, J., Johnson, G., Langlands, J., Kwan, C., Kanekal, S., Schwartz, R., Steino, A. and Brown, D. (2021). CTNI-21. Phase 2 study of VAL-083 and radiotherapy in newly diagnosed MGMT unmethylated GBM. Neuro-Oncology, 23(Supplement_6), vi63-vi64. doi:10.1093/neuonc/noab196.246

O'Brien, B., Penas-Prado, M., Kamiya-Matsuoka, C., Weathers, S.-P., Yung, W. K. A., Loghin, M. Harrison, R., Majd, N., Knight, S., Bacha, J., Brown, D., Steino, A., Johnson, G., Kanekal, S., Langlands, J., Lopez, L., Schwartz, R, Penas-Prado, M DeGroot, J. (2021). CTNI-26. Phase 2 study of dianhydrogalactitol (VAL-083) in patients with MGMT-unmethylated, bevacizumab-naïve glioblastoma in the recurrent and adjuvant setting. Neuro-Oncology, 23(Supplement_6), vi65-vi65. doi:10.1093/neuonc/noab196.251

Burgoyne, D., DeBruin, E., Hatfield, N., & Langlands, J. (2022). Effect of N0651 on ocular inflammation in endotoxin-induced uveitis and autoimmune uveitis in the rat. Investigative Ophthalmology & Visual Science, 63(7), 2125-F0141.

Sarah Truong, Beibei Zhai, Fariba Ghaidi, Louise Ramos, Jay Joshi, Dennis Brown, Neil Sankar, John Langlands, Jeffrey Bacha, Wang Shen, Poul Sorensen, Mads Daugaard; Abstract A024: In vitro efficacy of a novel dual PARP-HDAC inhibitor in Ewing sarcoma. Clin Cancer Res 15 September 2022; 28 (18_Supplement): A024. https://doi.org/10.1158/1557-3265.SARCOMAS22-A024

Kamiya-Matsuoka, C., Knight, S., Langlands, J., Brown, D., & Puduvalli, V. (2022). DDDR-34. Recurrent RELA fusion-positive ependymoma treated with VAL-083 under expanded access: a case report. Neuro-Oncology, 24(Supplement_7), vii106-vii106. doi:10.1093/neuonc/noac209.399

Kamiya-Matsuoka, C., Majd, N., Harrison, R., Knight, S., Langlands, J., Brown, D., & Puduvalli, V. (2022). DDDR-36. VAL-083 in patients with recurrent glioblastoma treated under expanded access program. Neuro-Oncology, 24(Supplement_7), vii107-vii107. doi:10.1093/neuonc/noac209.401

Kamiya-Matsuoka, C., Knight, S., Hanna, T., Gregory, T. A., Langlands, J., Brown, D., & Puduvalli, V. K. (2023). Abstract LB126: RELA fusion-positive ependymoma and diffuse midline glioma treated with VAL-083 under expanded access - case reports. Cancer Research, 83(8_Supplement), LB126-LB126. doi:10.1158/1538-7445.Am2023-lb126

Kamiya-Matsuoka, C., Weathers, S.-P., Harrison, R. A., Majd, N. K., Aaroe, A. E., Knight, S., . . . Puduvalli, V. K. (2023). Abstract LB127: VAL-083 in patients with recurrent glioblastoma treated under expanded access program. Cancer Research, 83(8_Supplement), LB127-LB127. doi:10.1158/1538-7445.Am2023-lb127

Truong, S., Ramos, L., Zhai, B., Joshi, J., Ghaidi, F., Marzban, M., . . . Daugaard, M. (2023). Abstract LB_C11: Small-molecule bifunctional inhibitors of PARP1/2 and HDAC enzymes. Molecular Cancer Therapeutics, 22(12_Supplement), LB_C11-LB_C11. doi:10.1158/1535-7163.Targ-23-lb_c11

Guo, C.-c., Yang, Q.-y., Xi, S.-y., Liao, Y.-X., Li, D.-p., Jiang, X.-b., . . . Chen, Z. (2023). CTNI-77. post-progression treatment after VAL-083 with radiation in newly diagnosed gbm mgmt unmethylated patients. Neuro-Oncology, 25(Supplement_5), v95-v95. doi:10.1093/neuonc/noad179.0359

Kamiya-Matsuoka, C., Weathers, S.-P., Yung, W. K. A., Loghin, M., Majd, N., Brown, D., . . . O'Brien, B. (2023). CTNI-78. Evaluation of post-progression treatments after VAL-083 in recurrent and newly diagnosed GBM MGMT-unmethylated patients. Neuro-Oncology, 25(Supplement_5), v95-v96. doi:10.1093/neuonc/noad179.0360

Guo, C., Yang, Q., Li, J., Wu, S., Cao, X., Deng, M., . . . Chen, Z. (2023). P11.41.b Phase 2 study of VAL-083 and radiotherapy in newly diagnosed MGMT-unmethylated GBM: case study reports. Neuro-Oncology, 25(Supplement_2), ii83-ii83. doi:10.1093/neuonc/noad137.275

Sarah Truong, Louise Ramos, Beibei Zhai, Fariba Ghaidi, Mona Marzban, Hans Adomat, Xiaoqi Chen, John Langlands, Dennis Brown, Jeffrey Bacha, Colin Collins, Poul H. Sorensen, Wang Shen, Mads Daugaard; Abstract LB273: Pharmacological synthetic lethality by co-inhibition of PARP and HDAC enzymes. Cancer Res 1 April 2024; 84 (7_Supplement): LB273. https://doi.org/10.1158/1538-7445.AM2024-LB273

Carlos Kamiya-Matsuoka, Shaio-Pei Weathers, Stephanie Knight, Teresa Hanna, John Langlands, Dennis Brown, Vinay Puduvalli, CTNI-71. RELA fusion-positive ependymoma, diffuse midline glioma and grade 4 IDH mutant astrocytoma treated with VAL-083 under expanded access: Case Reports , Neuro-Oncology, Volume 26, Issue Supplement_8, November 2024, Page viii113, https://doi.org/10.1093/neuonc/noae165.0438

Carlos Kamiya-Matsuoka, Shaio-Pei Weathers, Rebecca Harrison, Nazanin Majd, Ashley Aaroe, Stephanie Knight, Teresa Hanna, Chirag Patel, john Langlands, Dennis Brown, Vinay Puduvalli, CTNI-72. VAL-083 in patients with recurrent glioblastoma treated under expanded access program, Neuro-Oncology, Volume 26, Issue Supplement_8, November 2024, Pages viii113–viii114, https://doi.org/10.1093/neuonc/noae165.0439

Sarah Truong, Fuqiang Ban, Jason Smith, Beibei Zhai, Louise Ramos, Mona Marzban, Fariba Ghaidi, Hans Adomat, Xiaoqi Chen, John Langlands, Dennis Brown, Jeffrey Bacha, Colin Collins, Artem Cherkasov, Mads Daugaard, DDDR-15. Utilizing deep docking and artificial intelligence for the discovery of novel PARP1-selective inhibitors for use against brain tumors , Neuro-Oncology, Volume 26, Issue Supplement_8, November 2024, Pages viii128–viii129, https://doi.org/10.1093/neuonc/noae165.0500

Carlos Kamiya-Matsuoka, Shaio-Pei Weathers, Alfred Yung, Monica Login, Nazanin Majd, Dennis Brown, John Langlands, Richard Schwartz, Stephanie Knight, Vinay Puduvalli, John de Groot, Barbara O’Brien, CTNI-73. Assessment of molecular alterations in newly diagnosed GBM MGMT-unmethylated patients treated with VAL-083 , Neuro-Oncology, Volume 26, Issue Supplement_8, November 2024, Page viii114, https://doi.org/10.1093/neuonc/noae165.0440

Carlos Matsuoka-Kamiya, John Langlands, Dennis Brown, CTP-05. VAL-083 for treatment of Histone H3-Wild Type Diffuse Midline Glioma, Neuro-Oncology, Volume 27, Issue Supplement_5, November 2025, Page v146, https://doi.org/10.1093/neuonc/noaf201.0577

Jeffrey Bacha, Sarah Truong, Fuqiang Ban, Jason Smith, Mohit Pandey, Ekaterina Manskaia, Beibei Zhai, Louise Ramos, Mona Marzban, Fariba Ghaidi, Hans Adomat, Kally Singh, Xiaoqi Chen, Dennis Brown, John Langlands, Colin Collins, Artem Cherkasov, Mads Daugaard, DNAR-06. Discovery and development of novel CNS-penetrating PARP1-selective inhibitors, Neuro-Oncology, Volume 27, Issue Supplement_5, November 2025, Pages v151–v152, https://doi.org/10.1093/neuonc/noaf201.0597

Jeffrey Bacha, Richard Daniels, Sarath Kanekal, John Langlands, Dennis Brown, DDDR-33. EO-4426: A brain-penetrant dual DNA-polymerase α and ribonucleotide reductase inhibitor for high-grade gliomas and other aggressive cancers, Neuro-Oncology, Volume 27, Issue Supplement_5, November 2025, Page v170, https://doi.org/10.1093/neuonc/noaf201.0670

Jeffrey Bacha, Sarah Truong, Beibei Zhai, Louise Ramos, Mona Marzban, Fariba Ghaidi, Marshall Drew-Brook, Pete Guzzo, Ahmad Issa, Mehran Khodabandeh, Sara Omar, Jason Rolfe, Seyed Ali Saberali, Kally Singh, Xiaoqi Chen, Dennis Brown, John Langlands, Mads Daugaard, DNAR-05. Discovery and development of a novel CNS-penetrating ATR inhibitor, Neuro-Oncology, Volume 27, Issue Supplement_5, November 2025, Page v151, https://doi.org/10.1093/neuonc/noaf201.0596

Sarah Truong, Beibei Zhai, Louise Ramos, Mona Marzban, Fariba Ghaidi, Marshall Drew-Brook, Pete Guzzo, Ahmad Issa, Mehran Khodabandeh, Sara Omar, Jason Rolfe, Seyed Ali Saberali, Kally Singh, Xiaoqi Chen, Dennis Brown, John Langlands, Jeffrey Bacha, Mads Daugaard; Abstract C116: Novel ATR inhibitors with CNS penetrance developed by artificial intelligence. Mol Cancer Ther 1 October 2025; 24 (10_Supplement): C116. https://doi.org/10.1158/1535-7163.TARG-25-C116

M de Lucas Sanz, H Allahverdi, B Nosirov, P Moreno Sanchez, M Baroni Milan, A Lipsa, M Rezaeipour, C Dording, D Brown, J M Langlands, K Grzyb, Y A Yabo, J Zhang, D H Heiland, A Michelucci, P V Nazarov, A Golebiewska, P01.18.B Modeling glioblastoma treatment responses: insights into tumor plasticity and the role of the tumor microenvironment, Neuro-Oncology, Volume 27, Issue Supplement_3, October 2025, Page iii33, https://doi.org/10.1093/neuonc/noaf193.098